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Some signs and symptoms of Vitamin B12 deficiency include jaundice, weakness, fatigue, mouth ulcers, dizziness, disturbed vision, etc.

Commonly used quenching methods in metabolomics studies include washing the culture plates and adding pre-cooled methanol or acetonitrile, or rapidly freezing the plates in liquid nitrogen

Sp' is a bond, -S-, -0-, -CONH-, -NHCO-, or --NR' wherein R' is as hereinbefore defined, with the proviso that when Alk' is a bond, Sp 1 is a bond

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