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2.2.1 Anti-oxidant effects Oxidative stress in the nigrostriatal pathway is a defining pathological hallmark of PD, and BL, as an endogenous antioxidant, can exert neuroprotective effects by attenuating DA neuron degeneration ( Mitochondrial dysfunction plays a pivotal role in PD-associated oxidative pathology through four interconnected mechanisms: progressive depletion of nigral glutathione (GSH

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1C), suggesting that cystine starvation induced the amino acid response but not the ER stress signaling within the ISR

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Atp5a1 : Mt-ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation