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Description
The pKa, defined as log Ka, is a concentration-independent measure of acid strength determined entirely by the intrinsic relative stability of the protonated and deprotonated forms a thermodynamic quantity directly related to G through the relationship G = RT ln Keq

The authors demonstrated that male PwPD presenting with HHcy had significantly lower levels of Vit B12 and more rapid motor progression

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J Intensive Care
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Methylcobalamin is the only active form of B12 found within the Central Nervous System (CNS)