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JAMA Internal Medicine

"The importance of folate, vitamins B6 and B12 for the lowering of homocysteine concentrations for patients with recurrent pregnancy loss and MTHFR mutations"

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Deficiencies in vitamin B12 can lead to symptoms like headaches, fatigue, irritability, depression, anxiety, numbness and tingling in extremities, digestive problems and even nerve damage and cognitive issues

Laboratory analysis of blood samples Fasting blood samples were collected for the measurement of fasting plasma glucose, fasting plasma insulin, glycated haemoglobin (HbA1c), lipid profiles, and adipokines