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In the cerebral and cerebellar cortex, hypothalamus/thalamus, and hippocampus, it appeared as congestion, edema, and a larger area with an increased number of karyopyknotic cells and intracerebral hemorrhage, mostly in the infratentorial space, affecting the cerebello-angle/area

It has the ability to inhibit the secretion of TNF- inflammatory factors, which can be used as evidence to support its claim of soothing effect

10.1152/ajpendo.00201.2006 2 ArajS

Together, however, they form a powerful synergy that enhances their healing capabilities, offering a solution for those seeking faster recovery from sports injuries, chronic pain, surgery, and other physical trauma

Commercial Development: In August 2025, Jocasta Neuroscience raised $35 million in Series A funding to advance JN-0413, a proprietary -klotho formulation, through Phase 1 trials with IND submission planned for Q4 2026