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The normal cellular function of C9orf72 is related to vesicular trafficking and autophagy (Farg et al., 2014) whereas SOD1 is an antioxidant enzyme that mediates detoxification of the superoxide anion radical (

mTORC2 interacts with IGF-IR, and phosphorylates IGF-IR at Y1131/1136 thereby activating IGF-IR [32]

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This difference matters because highly tissue-specific bioregulators often behave differently than systemic repair peptides
