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Proline-containing dipeptides, which are relatively resistant to hydrolysis, are the primary peptides present in the circulation

Cystatin C is associated with risk of venous thromboembolism in subjects with normal kidney function--the Tromso study

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High levels of HO inactivate protective peptides like ACTH and -MSH, while decreasing enzyme activities like methionine sulfoxide reductase, consequently intensifying oxidative damage and accelerating melanocyte death 46

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