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Kang L, Jiang D, Ehlerding E, Barnhart T, Ferreira C, Wang R, et al

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CFTR -/- mice had enhanced intracellular Ca 2+ flux in response to T cell receptor (TCR) activation on T effectors cells, higher interleukin (IL) 4, IL-13, IgE and IgG1, this prominent Th2 bias correlated with higher nuclear NFAT level than their wild type control littermates (CFTR +/+ )