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Partial inhibition by daratumumab could not be overcome by increasing antibody concentrations, as evidenced in additional experiments with both recombinant CD38 protein and CD38-expressing cells [23]

Moreover, these macrocyclic peptides have been observed to downregulate MNAM production in cellular assays

AOD-9604, or Anti-Obesity Drug-9604, is a synthetic peptide fragment derived from the C-terminal end of human growth hormone (HGH)