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The consequences of this condition can include cell and tissue dysfunction, disruption of metabolic processes, and even premature aging

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Patients who develop symptoms of unexplained hyperammonemic encephalopathy while receiving valproate therapy should receive prompt treatment (including discontinuation of valproate therapy) and be evaluated for underlying urea cycle disorders (see Contraindications and Hyperammonemia and Encephalopathy Associated with Concomitant Topiramate Use as follows)

Yes, sitting for hours causes fatigue by deconditioning your body