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Statements Author contributions HR designed the study, wrote the first draft, and prepared the graphical illustrations

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Biofilm formation was measured by measuring bacterial density at OD 600nm using a plate reader (Tecan infinite M1000 pro, Melbourne, Australia)

Further, an LPS administration model of systemic inflammation in sepsis in conjunction with convulsant PTZ treatment in mice increased seizure susceptibility, which was attenuated with NOX2 genetic ablation and inhibition ( Epileptic encephalopathies and genetic epilepsies such as West, Lennox-Gastaut, Dravet, Lafora, and Leigh syndromes have additionally shown evidence of gliosis and neuroinflammation in humans (You et al., 2009