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Glutathione-deficient mice are susceptible to TCDD-Induced hepatocellular toxicity but resistant to steatosis

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In human AML stem cells, BCAT1 is overexpressed, and the BCAA pathway is activated by the low levels of -KG, displaying a DNA hypermethylation phenotype similar to IDH mutant-positive cancers (Raffel et al., 2017)

One small open-label study that provided 2530 g/kg/day (1500 g/day maximum) of methylcobalamin to 13 patients found no adverse effects ( N -acetyl-l-cysteine, one as a primary treatment and another as an add-on to risperidone