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Growth retardation and skeletal abnormalities arise from disrupted nucleic acid metabolism and impaired osteoblast activity [5, 6]

Similarly, adipose tissue, in particular visceral fat, secretes pro-inflammatory adipocyte-derived cytokines and exhibits higher levels of C-reactive protein (CRP), TNF- receptor 2, and IL-6 than non-obese individuals ( The association between SLE risk and diet is less clear in humans ( Several studies have reported an association between lack of sleep and SLE risk in humans (93102)

T2DM was induced in rats through a single intraperitoneal injection of a freshly prepared STZ solution (35 mg/kg) [58,59,60] diluted in citrate buffer (0.01 M, pH = 4.5) following a 14-h fasting period

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