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Nemluvio also significantly alleviated itch and reduced sleep disturbances as compared with placebo

After 4 weeks of oral administration of 5amino1mq tablets (510 mg/kg) to aged mice (1820 months old), muscle mass was significantly increased, grip strength was enhanced by approximately 40% compared with the control group, and muscle endurance and exercise capacity were also notably improved.Further studies revealed that 5amino1mq inhibits excessive NNMT activation in muscle tissue, restores NAD levels, activates the SIRT1 pathway, reduces muscle protein degradation, and promotes muscle protein synthesis, thereby maintaining muscle mass

New England Journal of Medicine 2013;368:2041

Based on the above, in this study, we aimed to investigate whether Dihexa improves the cognition of APP/PS1 mice and whether the brain AngIV/PI3K/AKT axis is a possible mechanism