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DIE lesions also exhibit increased SK1, S1P 3 and S1P 5 mRNA levels and the expression of a specific S1P transporter, Spns2, responsible for the extracellular release of S1P, is altered only in DIE, further highlighting the dysregulation of S1P signalling in the different forms of endometriosis [15] (Fig

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Collectively, these data confirm the efficacy of CBD against depressive-like behavior and reveal a synergistic therapeutic benefit when it is combined with alpha-lipoic acid