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Malignant cancer cells can invade nearby tissues or organs and can also travel to distant places in the body through blood or the lymphatic system, and consequently form a new tumor far away from the original one
Phase II trials were initiated to investigate the efficacy of BMS-754807 as a single agent and in combination with the aromatase inhibitor letrozole (NCT01225172) and OSI-906 in combination with hormone therapy and the EGFR tyrosine kinase inhibitor erlotinib (NCT01205685) but were ultimately terminated or withdrawn
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