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Intestinal microbiota-dependent metabolism of dietary phosphatidylcholine might also be involved in the pathogenesis of cardiovascular disease (see Safety) (23, 24)

251,252 In IR-induced organ injury, ischemia and hypoxia dampen the PI3K-AKT pathway, increasing cellular sensitivity to apoptosis and exacerbating organ damage, particularly in the brain and intestines

Intrinsic skin aging is linked to reduced cell replication capacity and the weakening of the extracellular matrix

The EFFIGACT study, a 6-month randomized controlled trial that enrolled and randomized 156 patients, showed that ACT was statistically superior to both the recommended pharmacological treatment (RPT: pregabalin + duloxetine) and the waiting list immediately after treatment, and improvements were maintained after 6 months [36, 37]

Studies show that chocolate high in flavanols can improve cognition in people with cognitive decline