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Elucidating its precise mechanistic contribution and hierarchical significance within this complex pathogenic network is essential for achieving fundamental theoretical insights and enabling successful clinical translation

Acknowledgments The authors gratefully acknowledge the foundational experimental contributions of previous researchers in the field of ferroptosis and periodontitis, whose pioneering work has informed and inspired this review

Protocol integration: Cerebrolysin 10-20mL IV 5 days weekly for 4 weeks quarterly plus GHK-Cu 1-3mg subcutaneous 3-5x weekly ongoing

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FDA peptide action: what changed and when April 15, 2026 the FDA announced the action (Federal Register notice April 16, 2026)