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Diabetes models show slower platelet Ca 2+ clearance after activation, matching reduced PMCA function despite unchanged PMCA expression levels (Millington-Burgess and Harper, 2021)
68,69 Both MTHFD2 and MTHFD1 are markedly elevated and correlated with poor survival across human cancers
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Furthermore, by inhibiting the A 3A AR-mediated internalization of the amyloid precursor, caffeine inhibited the amyloid formation and showed a protective effect [72]
