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Because melanin synthesis is regulated by estrogen, dropping estrogen levels post-menopause are thought to be the primary triggers of age spots in women

NICE guidance recommends early referral (within 3 working days) for suspected persistent synovitis to enable prompt initiation of disease-modifying therapy where appropriate

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And it's the main reason why foot injuries that would heal quickly in a muscle can drag on for months or years in a tendon

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