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doi:10.1055/s-0034-1390481

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However, they are not widely used is the clinical practice due to the lack of sufficient data describing their potential function [20]

Recent neuroimaging and neurophysiological studies indicate that the motor cortex (CRTX) is both structurally and functionally affected in SMA patients, with variations in cortical changes correlating with disease severity and phenotype, suggesting the coexistence of compensatory and maladaptive plasticity alongside neurodegeneration

[6] According to the University of Maryland Medical Center, L-carnitine is safe for use in combating fatigue and improving exercise performance, "but may not help much." [4] Potential side effects Taking too much L-carnitine, about 5g, can cause digestive upset, abdominal pain, vomiting, and diarrhea, though these symptoms cease once you lower your dosage (start by cutting it in half), or stop taking it completely