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IL6 derived from macrophages under intermittent hypoxia exacerbates NAFLD by promoting ferroptosis via MARCH3led ubiquitylation of GPX4

This shifts substrate preference toward lipids over glucose, increasing reliance on -oxidation and aggravating metabolic stress (van Gerwen et al., 2023)

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However, GSH levels tend to decrease with aging and in various age-related neurodegenerative diseases, especially Alzheimers disease, the most prevalent form of dementia affecting the elderly 11,12,13