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Table 2 Molecules targeting ferroptosis in IBD
The intramolecular thiolate group is released from its disulphide-bound form by reaction with a thiolate group from cysteine or glutathione and the intramolecular nucleophile triggers the reaction cascade leading to the formation of three lanthionine-bound molecular units within the amino acid sequence of MT and of three units of cadmium sulphide
105 This presents unique clinical challenges and management considerations
Requesting mass spectrometry data under reducing and non-reducing conditions can help identify these isomers, as can specific bioactivity assays in validated cell lines
Given that TNF directly induces oligodendrocyte death in vitro [225, 226], it may directly participate in cuprizone-induced demyelination in vivo
