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Elemental imbalances in the olfactory pathway in Alzheimers disease

Spironolactone directly inhibits proliferation of cultured human facial sebocytes and acts antagonistically to testosterone and 5alpha-dihydrotestosterone in vitro

Patients were randomly assigned to L-carnitine (510 mg/day), followed by placebo or vice versa

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The discrepancy between these findings and our APOE23 AD iMG results likely reflects the cell-autonomous nature of our model, which does not capture the influence of the broader cellular and systemic environment present in vivo