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These misfolded proteins accumulate in neurons, leading to selective degeneration of striatal neurons and progressive motor and cognitive deficits (397)

doi: 10.1249/MSS.0b013e31820b88bc
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The preference of mammalian and bacterial glutaredoxins for GSSR highly depends on the -glutamyl moiety of glutathione 40,41,42

The list of medicines that are commonly prescribed in those cases includes Lyrica, Cymbalta, and Neurontin
