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10.1158/1541-7786.MCR-22-0056 133 SuwaraJ.HartmanM

Dark circles are a relatively common condition, but can become very noticeable leading us to feel self-conscious

Lower blood volume means the heart must contract slightly harder to maintain blood pressure, and that increased contractility can feel like palpitations

Keywords: ME/CFS, neuroimmune, neurological disorders, sleep disturbance, AQP4 water channels, glymphatic system, glymphatic dysfunction 1

OS arises from a disruption in redox homeostasis, where an overproduction of reactive oxygen species (ROS) overwhelms endogenous antioxidant defenses, leading to oxidative damage to lipids, proteins, and DNA (Sies et al., 2024)