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In glioma therapy, a recent paper reported a new nanoparticle-mediated drug delivery system that patches heparin-based nanoparticles loaded with DOX to the surface of natural grapefruit extracellular vesicles (205), however, it didnt mention whether this system could trigger ferroptosis in glioma cells

10.1016/j.copbio.2012.08.005 [DOI] [PubMed] [Google Scholar] McGuire S

The substrate features recognized by the E3 ligase do not conform to a conventional degron 14,15 but instead establish a two-RNA-factor authentication mechanism for specifying a protein ubiquitylation substrate

Theranostics 12 , 43104329 (2022)

Energy Crisis: A surge in energy demand paired with a reduced ability to produce ATP (the cells energy currency)