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Chen DS, Mellman I

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However, their efficacy in the progressive course of the disease is limited ( While the proinflammatory and neurotoxic properties of glial cells in MS have been of interest for a long time, only recently has their protective potential become a topic of interest ( Thus, glial cells exert part of their protective functions by the release of so-called neurotrophic factors ( 1.1 Neurotrophic factors Neurotrophic factors (NTFs) comprise a family of secreted proteins which are essential for the development, survival and function of neurons in the nervous system ( Neurotrophins are initially synthesized in the endoplasmic reticulum as precursors called proneurotrophins which are then processed into mature neurotrophins ( As outlined, NTFs play an important role in modifying inflammation in the CNS and controlling neurodegeneration, which both are central in MS