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Furthermore, microsomal PGE synthase 1 (mPGES1) and PGIS are coupled with COX2 at the perinuclear membrane, and preferentially produce PGE 2 and PGI 2 during the later phase of the LPS-induced response (324 hours of stimulation) 36,37
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If nausea persists or interferes with meals, consult a healthcare provider for possible dose adjustment
Pharmacology & Therapeutics, 99(1), 45-53.
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