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Pre-clinical animal models also shed new light on possible mechanisms of CIPN, including abnormal cytoskeletal architecture, disrupted axonal transport, mitochondrial dysfunctions, altered neuronal excitability in peripheral neurons, and neuroinflammation

Abnormal levels of copper can lead to dysregulation of lipid metabolism and increased fat accumulation, thereby heightening the risk of obesity (117)

The Pentraxins 19752018: Serendipity, Diagnostics and Drugs

doi: 10.1038/s41514-020-0042-x 81 Van LaethemAClaerhoutSGarmynMAgostinisP