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This suggests that the single-protofilament forms may represent immature or structurally less stable amyloid species, which are challenging to analyze at high resolution under the conditions applied in this study

in some cases, the friction of the toenails could induce trauma in the capillaries, thus leading to the appearance of red spots or splinter hemorrhages that reinforce the traumatic etiology of the pigmented band

There are two cell types present (biphasic), arranged in alveolar or tubular configurations

Of the melanocortin receptor-targeted compounds, only bremelanotide, an MC 4 agonist, has entered into clinical trials
