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The upregulated cellular iNOS protein level will then lead to increased production and accumulation of cellular NO
Plant Mol Biol Rep 33(5):14131427
However, if modified (PEGylation or ligand-functionalization), PLGA nanoparticles could escape the RES clearance, allowing longer systemic plasma half-life and accumulation in the CNS 99
10.1007/978-3-030-20301-6_2 18 CuiL.ZhangF.WangQ.LinH.YangC.ZhangT.et al (2015)
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