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leads to a value of -253.6 kcal mol-1 for the solvation free energy of the proton, which can be compared with the value of -263.5 kcal mol-1 obtained by Kelly et al
B.GretherJ

They are generally well tolerated, even with repeated administration

Rectal absorption could be also compared to transdermal (through the skin) absorption due to the anatomy of the rectum

2) It is found naturally in animal products (meat, eggs, fish, dairy)