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Psychological stress, exercise, pregnancy, breastfeeding, a high metabolic rate, sickness, inflammatory diseases, diabetes, and excessive urination can deplete thiamine quickly (sometimes in a day), increasing the need for it

A: Benefits like appetite reduction and weight loss may be observed within weeks, but individual responses vary

[8] The scientific community has known for over 30 years that single-dose oral glutathione (150 mol/kg) produced no detectable plasma increases over 4.5 hours in healthy adults