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Our finding that several diseases show lowered blood NAD + levels and overall imbalanced redox metabolites is intriguing, as it suggests that a variety of disease processes increase NAD + usage, potentially by activated repair processes including PARP enzymes a major user of NAD +8 .The results have high potential relevance for clinical and research applications, follow-up of metabolic interventions and detection of disease-induced NAD + or glutathione deficiency to select patients for treatment

But heres the problem: your glutathione levels naturally decline as you age

doi: 10.3389/fnagi.2017.00424 67 VitalePSalgueiro-PereiraARLupascuCAWillemMMiglioreRMiglioreMet al

Sex differences in peripheral and central dysregulation of the kynurenine pathway in Parkinsons disease