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Metals present on the particle surface, including Fe, Co, Cr, and V, undergo redox cycling, while Cd, Hg, and Ni, as well as Pb, deplete glutathione and protein-bound sulfhydryl groups, resulting in ROS production 17,18,19,20

The crystal structure of compound 6 combined with the KRAS (G12C)-GDP complex clearly indicates that compound six extends from Cys12 into an adjacent pocket named the switch-II pocket (S-IIP), rather than binding to the nucleotide pocket 117

G., Budd S

Supplementation with CoQ 10 significantly increases mitochondrial CoQ 10 content and restores the electron transport chain defect [198]

One study demonstrated that exposure to PS-NPs during pregnancy induces cardiac fibrosis in adult mouse offspring, with a more pronounced effect in female offspring compared to male offspring