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NRF2 is the master switch of the cellular antioxidant response: when oxidative stress is sensed, KEAP1 (the NRF2 repressor) is oxidized at critical cysteine residues, releasing NRF2 for nuclear translocation and ARE-driven upregulation of the complete antioxidant gene set including GCLC, GCLM, GSR, GPX1, GSTP1, and the thioredoxin system

Mackowski S

186 They found GNV reduces the toxicity of the polyethylenimine, which was used for the load of RNA, and FA-GNVs show better targeting behavior than GNVs with rapid movement into the brain within 1.5 h

doi: 10.1093/jas/skaa138

Oxidative stress (OS) refers to the imbalance between the oxidation system and antioxidation system in the human body, which is associated with the occurrence and development of various diseases