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According to the evidence demonstrating altered gut microbiota diversity or composition in obesity (53), remodeling the gut microbiota through pro/pre/synbiotic supplementation is speculated as a promising preventive/therapeutic strategy in obesity (24, 25)

Increased marrow adipogenesis does not contribute to age-dependent appendicular bone loss in female mice

However, more high-quality research is needed to confirm these effects and establish appropriate dosing parameters

The potential covariates included source, carnitine dosage, initial body weight, and age

It is established that protein-restriction diet alleviates metabolic changes in patients with PA 5