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High-molecular weight HA can inhibit this inflammatory response to a certain extent by inhibiting the effects of the low-molecular weight form (71) through competition for receptors or interference with the associated signal transduction pathway (72)

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GF contributed to the experimental design and data analysis and reviewed the manuscript

The main adverse events reported by male AAS users to SERMs (clomiphene and tamoxifen) were decreased libido and erectile dysfunction (24%), acne (21%), fatigue (19%), mood disorders (13%), visual disturbances (5%), arthralgia (4%), insomnia (4%), and hot flushes (2%)