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Suitable diagnostic and/or therapeutic agents, pharmaceutically acceptable nanocontainer for such agents, as well as suitable ligands for glutathione transporters for use in the conjugates of the invention are further defined herein below

Biochim Biophys Acta 268:305312 Terai Y, Ueno H, Ogawa T, Sawa Y, Miyagi A, Kawai-Yamada M, Ishikawa T, Maruta T (2020) Dehydroascorbate reductases and glutathione set a threshold for high-lightinduced ascorbate accumulation

Sources: Neelakantan H, Brightwell CR, Graber TG, et al

Additionally, chronic alcohol intake can inhibit the Nrf2-ubiquinol cytochrome c reductase core protein 2 (UQCRC2) pathway and suppress mitophagy activity by downregulating adenosine monophosphate-activated protein kinase (AMPK) gene expression

It is a trend to move faster into human It is inline with the trend that more regulatory bodies and countries are changing the rules to move away from animal testing and move into human faster