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Conversely, SLC25A39 overexpression partially restored protein levels diminished by AFG3L2, attenuated the suppressive effects of AFG3L2 on tumor cell growth and motility, and reduced apoptosis

In this regard, our in vitro experiments evidenced that under GSH depletion the increased NO availability induced S-nitrosylation of nuclear resident p53 at different cysteine residues, among which the Cys124 was essential for the induction of p53-mediated antioxidant response in C2C12 myoblasts

PMID 15868397

The type and position of amino acids in the active site of GSTs (G-site and H-site) play important roles in substrate binding affinity and catalytic function [74]

In the present study, we established a rat model of -cell failure using LOsG and found that high glucose promoted PSC activation and proliferation to enhance pancreatic fibrosis