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The different outcomes can be explained on the one hand due to the different host environments, namely intact retinas (Kinouchi et al., 2003) or intact hippocampi on the Rag-1 knock-out background (Widestrand et al., 2007), compared to ischemic cortical stroke combined with immunosuppression by cyclosporine A (Laterza et al., 2018)

Lezak, K

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Copper causes cuproptosis by binding to lipid-acylated components of the tricarboxylic acid cycle, leading to protein aggregation, loss of iron-sulfur cluster proteins, and eventually proteotoxic stress

On the other hand, overproduction of glutathione in tobacco mutants, as reported by Knstler et al