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In human and rat HSC lines, activated AMPK Inhibited TGF--Induced fibrotic responses of HSCs by regulating transcription co-activator P300 without altering TGF--induced Smad3 phosphorylation, nuclear localization, and Smad3 promoter binding activity

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In colonic tissue models, gabapentin was associated with: Reduced mast cell density or activation markers Decreased release of inflammatory mediators Improvement in visceral pain signaling These findings suggest gabapentin may exert indirect mast cellregulating effects within colonic tissue in experimental models

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