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90,91 Additionally, the activity of epigenetics-modifying enzymes and their cofactors, such as TET and -ketoglutarate (-KG) from the tricarboxylic acid cycle (TCA), can be influenced by abnormal metabolite levels in patients with metabolic diseases, further disrupting epigenetic regulation and exacerbating disease progression

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The genetic variants then provide the opportunity to investigate whether there is an association between genetically-determined serum UA and PD

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Yoshida, K., Murata, M., Yamaguchi, T