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Analysis of clinical data clearly demonstrates that mitochondrial dysfunction accompanies disease progression in a substantial proportion of patients

Avoid alcohol and medicines that interfere with DAO

Ling X, Marini F, Shi Y, R-Y W, Schober W, Yuan X, Andreeff M

glutamicum were shown to contribute to the low p K a value of the active site cysteine 37,38

Indications: Huntington's Chorea (a hyperkinetic movement disorder) A drug of first choice for this condition Side Effects: Sedation Depression (suicidal tendencies) Parkinsonism symptoms Lacks the hypotensive & GI side effects of reserpine due to its selectivity for central VMAT2 Pharmacokinetics: * undergoes rapid hepatic metabolism involving carbonyl reductase and CYP2D6 to 2 active metabolites -dihydrotetrabenazine (-HTBZ) and -dihydrotetrabenazine (-HTBZ), with eventual renal elimination of metabolites the -HTBZ and -HTBZ metabolites are primarily responsible for the pharmacological & therapeutic effects produced by the parent prodrug Readily crosses the blood brain barrier & depletes cerebral monoamine stores