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182 During cerebral I/R injury, the inhibition of Wnt/-catenin signaling leads to mitochondrial damage, including excessive mitochondrial fission, 169 cyt c release, caspase 9 activation, 181 and subsequent caspase three activation, ultimately resulting in cell apoptosis

[DOI] [PubMed] [Google Scholar] 26.Len F.O.S., Viebahn-Haensler R., Lpez C.G., Serrano E.I., Hernndez M.Y., Delgado R.L., Tamargo S.B., Takon O.G., Polo V.J.C

Fluorescein (FITC) Tunel Cell Apoptosis Detection Kit and Hematoxylin & Eosin dye were purchased from Wuhan Sevicebio Technology Co., Ltd

These encompass endogenous enzymes, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), and exogenous compounds acquired from the diet, including vitamins C and E, carotenoids, and polyphenols

Intervention strategies targeting catalase have shown protective effects against oxidative stress, highlighting the potential of catalase-based interventions in managing and treating cardiovascular diseases [69]