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Petrelintide exhibits a potent balanced agonistic effect on both the AMYR and CTRwhich precludes this molecule from being included in the DACRA class [116]

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Raman spectroscopy verified the existence of this compound by the appearance of the S-N stretching and the S-N = O bending modes at 522 cm 1 and 888 cm 1 , respectively

found that irisin-mediated p53 reduction decreases ferroptosis and protects cardiomyocytes against high-glucose injury by increasing SIRT1, decreasing p53 K382 acetylation to promote p53 degradation, and consequently upregulating SLC7A11 and GPX4 [108]