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Curcumin shows neuroprotective effects by stabilizing mitochondrial membrane potential, inhibiting cytochrome c release and subsequent caspase-3 activation, leading to reduced apoptosis (Jayaraj et al., 2013)

Lesions can also be found in extrapelvic locations such as the bowel, bladder, diaphragm, pleura, pericardium, or even the central nervous system [3]

Mangum JE, Hardee JP, Fix DK, Puppa MJ, Elkes J, Altomare D, et al

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Adjunct drugs such as catechol-O-methyltransferase (COMT) and monoamine oxidase-B (MAO-B) inhibitors lack specificity to the central nervous system (CNS), have poor BBB permeability, and result in systemic side effects 15,16