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The quantity and types of nutrients affect metabolic and aging-related pathways (3), and shape the gut microbiome, including microbial diversity, composition, and metabolite production

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1 Several pharmacologic treatments including lithium, anticonvulsants, and antipsychotic medications have demonstrated efficacy in the depressed phase of bipolar disorder, 2,3 but many patients fail to respond or cannot tolerate first-line mood-stabilizer treatments