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Abbreviations ABC ATPbinding cassette ApN aminopeptidase N BSO buthionine sulfoximine CysGly cysteinylglycine EAATs excitatory amino acid transporters GCL glutamatecysteine ligase GCLm modifier subunit of GCL GlyT glycine transporters GPx glutathione peroxidase(s) GR glutathione disulfide reductase GSB glutathionebimane adduct GSH glutathione GSSG glutathione disulfide GST glutathione Stransferase LDH lactate dehydrogenase Mrp multidrug resistance protein(s) MRS magnetic resonance spectroscopy MTT 3(4,5dimethyl2thiazolyl)2,5diphenyl2Htetrazolium bromide NAC Nacetyl cysteine PPP pentosephosphate pathway PrP prion protein ROS reactive oxygen species GluCys glutamylcysteine GT glutamyl transpeptidase 1

doi: 10.1007/s00204-017-2074-y 91 SilvaJPKohlerMGraffCOldforsAMagnusonMABerggrenPOet al

Researchers examined factors like body temperature and oxygen levels during acute infection and their effects on immune and stress pathways, as well as neuropsychiatric symptoms in individuals with long COVID

Additional findings supportive of hemolysis (indirect hyperbilirubinemia and elevated LDH levels) can also be seen

Available evidence indicates that NFPS binds to an extracellular site on GlyT1, with findings suggesting a preferential interaction with the outward-facing conformation of the transporter